If you’ve been searching for a way to improve skin quality without the “filled” look of traditional injectables, a polynucleotide treatment may be exactly what your skin needs. Our polynucleotides treatment harnesses the body’s natural repair processes to rejuvenate skin from within, offering results that look and feel genuinely natural.
Polynucleotides are highly purified DNA fragments derived from salmon sperm cells, developed for use in regenerative medicine and aesthetics. Unlike dermal fillers that add volume, these injectable treatments work at the cellular level to stimulate your skin’s own repair and regeneration processes.
Think of polynucleotides as powerful bio-stimulators. When injected into the skin, these DNA fragments derived from salmon signal your cells to repair damaged skin cells, produce new collagen and elastin, and restore youthful skin quality from within.
At The Doctors Practice, we use CE-marked, clinic-grade polynucleotide products commonly used across UK medical aesthetics. These purified DNA fragments undergo rigorous processing to ensure less than 0.1% protein contamination, minimising any risk of allergic reactions.
At The Doctors Practice in Edgbaston, Birmingham, we specialise in advanced regenerative aesthetics that go beyond surface-level fixes. Our doctor-led approach means every treatment is tailored to your individual skin concerns, lifestyle and goals.
The Doctors Practice is a CQC regulated medical aesthetics clinic based in Edgbaston, Birmingham, and, led by Dr Rinku and Dr Bik. Our team brings together extensive experience in general practice and advanced aesthetic medicine, ensuring that your safety and results are never compromised.
We offer advanced polynucleotide injections using salmon DNA and PDRN-based injectable treatments for skin rejuvenation. Whether you’re concerned about under-eye dark circles, facial fine lines, neck creases or ageing hands, our polynucleotides treatment protocols are designed to deliver visible, lasting improvement.
Polynucleotides are of of the most effective skin treatments of 2026.
20 Minutes
4 Weeks After
None
Mild
From £300
12+ Months
Every patient at The Doctors Practice begins with a thorough medical consultation at our Edgbaston clinic.
Step 1 – Consultation
Your journey starts with a comprehensive assessment including:
Step 2 – Treatment Plan
Following assessment, we agree on:
Step 3 – Treatment Day
The treatment involves:
Step 4 – Aftercare
Immediately following treatment:
You’ll be reviewed at subsequent visits so we can monitor your progress and accelerate tissue repair through protocol adjustments if needed.
Patient safety is our absolute priority at The Doctors Practice. Polynucleotides have an excellent safety profile, particularly when administered by experienced doctors using pharmaceutical-grade products.
Our safety standards:
Common temporary side effects:
Most side effects are mild and resolve quickly:
Rare risks:
Though uncommon, we discuss the following during your consent process:
The minimal downtime associated with polynucleotide treatment means most patients return to work and normal activities the same day or within 24 hours. Some prefer to schedule treatments before a quiet weekend, particularly when treating visible areas like under-eyes.
Over 200 5-Star Google Reviews
Safe & Luxurious Clinic Rooms
Evening & Weekend Availability
Competitive & Transparent
As a CQC regulated, doctor-led clinic based in Edgbaston, The Doctors Practice provides a level of expertise and safety that sets us apart from non-medical providers. We serve patients from across Birmingham and surrounding areas including Wolverhampton, Walsall, Solihull and Sutton Coldfield.
The treatment involves precise injections placed just beneath the skin’s surface, where polynucleotides activate fibroblasts, the cells responsible for producing collagen and elastin. Research shows these DNA fragments can stimulate fibroblast proliferation rates of 150-200% in laboratory studies.
The biological mechanisms include:
Results are gradual rather than instant. Early changes in skin hydration and glow often appear within 2-3 weeks, with more significant improvements in skin firmness, texture and elasticity becoming noticeable around 6-12 weeks after completing a treatment course.
Polynucleotides at our Edgbaston skin clinic can address both early and more advanced signs of ageing, as well as specific texture, pigmentation and skin quality concerns. Clinical studies show patients experiencing 40-60% improvement in elasticity and hydration after a course of three sessions.
Facial concerns:
Under-eye concerns:
Scarring and pigmentation:
Neck, décolletage and hands:
Polynucleotides can also support skin repair and recovery after procedures such as microneedling, chemical peels or laser treatments, enhancing long term skin regeneration when integrated into a comprehensive treatment plan.
Polynucleotide treatment suits a wide age range, from late 20s through to 70s and beyond. Candidacy focuses on your individual’s skin condition and concerns rather than chronological age alone.
Ideal candidates include:
Polynucleotides work well across all skin tones, including darker skin types, due to the low risk of pigment disturbance when performed correctly by trained practitioners.
An in-person consultation with Dr Rinku or Dr Bik at our Edgbaston clinic is essential to confirm your suitability, discuss realistic expectations, and design a treatment plan matched to your specific skin concerns.
At The Doctors Practice, we can precisely target specific treatment areas, often combining multiple regions across a treatment course for comprehensive skin rejuvenation results.
Treatment Area | Common Concerns Addressed |
|---|---|
Full face | Overall skin quality, firmness, glow |
Cheeks & temples | Volume-related texture changes, laxity |
Forehead | Fine lines, crepey texture |
Under-eyes | Dark circles, puffiness, thin skin |
Crow’s feet | Lines around delicate areas |
Neck | Necklace lines, horizontal creases |
Décolletage | Sun damage, crepey chest skin |
Hands | Thinning skin, visible veins, texture |
Treatment plans can focus on a single area (such as under-eyes only for reducing dark circles) or combine multiple zones such as face and neck courses. The approach is explained clearly during your consultation, ensuring you understand exactly what each session targets.
For patients concerned about hair follicles and hair density, some polynucleotide protocols can be used as adjunctive therapy, please discuss this with Dr Rinku or Dr Bik if relevant to your concerns.
Certain conditions require additional caution or may mean polynucleotides aren’t appropriate:
Smoking can reduce treatment efficacy by 15-20%, so we discuss this during consultation and may recommend lifestyle modifications for optimal results.
If you have complex medical history, we may request a letter from your GP or specialist before proceeding. Honest disclosure during consultation ensures we can provide safe, appropriate advice and recommend alternative options if polynucleotides aren’t right for you.
Understanding the differences between treatments helps you make informed decisions about your skin health. Here’s how polynucleotides compare:
Polynucleotides Birmingham:
Hyaluronic acid dermal fillers:
Hyaluronic acid skin boosters (e.g., Profhilo):
At The Doctors Practice, we often recommend a combination approach. For example, polynucleotides first to improve overall skin quality and establish healthy tissue repair, followed by carefully placed filler or anti wrinkle injections if appropriate for your goals.
The choice of treatment is always made after a full facial assessment with one of our doctors. We’ll never recommend treatments you don’t need. Our focus is on results that genuinely benefit your skin.
While many skin boosters focus mainly on hydration (often through hyaluronic acid), polynucleotides work at a cellular level. They stimulate fibroblasts, support tissue repair and improve the skin’s biological environment. This makes them particularly effective for skin that is damaged, inflamed, or showing signs of stress rather than just dehydration.
They can be. Polynucleotides are increasingly used as a preventative treatment in younger patients who are experiencing early signs of skin fatigue, acne scarring or environmental damage. Rather than changing facial structure, they support long-term skin health and slow visible ageing.
Polynucleotides may improve the appearance of certain scars by promoting tissue regeneration and improving skin elasticity. They are particularly helpful for post-inflammatory skin, such as acne-prone or sensitised skin, where calming inflammation and supporting repair is a priority.
Written by Dr Rinku Ratti – Aesthetic Doctor and Women’s Wellness Expert at The Doctors Practice Microneedling & Polynucleotides: A Powerful Duo at The Doctors Practice The Future of Skin Rejuvenation: Microneedling Combined with Polynucleotides You may already be familiar
Written by Dr Rinku Ratti, Skin and Aesthetic Doctor at a doctor-led private GP and aesthetic clinic – The Doctor’s Practice Topical Steroid Withdrawal (TSW) is a complex and often distressing condition that can significantly affect both physical comfort and
Written by Dr Rinku Ratti – Aesthetic Doctor, The Doctors Practice, Birmingham Exosomes & Purasomes: A New Era in Skin Regeneration In the world of aesthetic medicine, few innovations excite us as much as exosome therapy. And now, with the
